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Dara L. Kraitchman, VMD, PhD

 

 


 

Dara L. Kraitchman, VMD, PhD, FACC
Associate Professor, Department of Radiology

Research Interests

 

 

 

 

Dr. Kraitchman's research interests are concentrated on non-invasive imaging and minimally invasive treatment of cardiovascular disease. She has been actively involved in developing new methods to image myocardial function and perfusion using MRI. Current research interests are aimed at determining the optimal timing and method of administration of mesenchymal stem cells to regenerate infarcted myocardium using non-invasive MR fluoroscopic delivery and imaging. MRI and radiolabeling techniques include novel MR and radiotracer stem cell labeling methods to determine the location, quantity, and biodistribution of stem cells after delivery as well as to noninvasively determine the efficacy of these therapies in acute myocardial infarction and peripheral arterial disease.

Recently, the first technique to provide radiopaque labeling of stem cells for x-ray fluoroscopic delivery and CT imaging of stem cell persistence for cardiac and peripheral arterial disease applications has been developed. These labeling techniques have been developed using FDA-approved contrast agents in large animal preclinical models of cardiovascular disease using clinical MR, radionuclide, and CT imaging scanners for rapid translation to the clinical realm. She is also focused on the development of new animal models of human disease for noninvasive imaging studies and the development of promising new therapies in clinical trials for companion animals.

 

 

 

 

 

Other Appointments:

Affiliations:

American Veterinary Medical Association
Institute of Electrical and Electronics Engineers
International Society for Magnetic Resonance in Medicine
Affiliate Faculty in Institute of Nanobiotechnology
Affiliate Faculty in Institute for Computation Medicine
Society of Cardiovascular Magnetic Resonance
Fellow of American College of Cardiology
American Heart Association

 

Publications:

  1. Kraitchman DL, Young AA, Axel L: Semi-automatic tracking of myocardial motion in MR tagged images. IEEE-Trans. Med. Imag. 1995 14(3): 422-433.
  2. Kraitchman DL, Wilke N, Hexeberg E, Jerosch-Herold M, Wang Y, Parrish T, Chang C-N, Bache RJ, Axel L: Myocardial perfusion and function in dogs with moderate coronary stenosis. Magn. Reson. Med. 1996 35:771-780.
  3. Kraitchman DL, Young AA, Bloomgarden DC, Fayad ZA, Dougherty L, Ferrari VA, Axel L: Integrated MRI assessment of regional function and perfusion in canine myocardial infarction. Magn. Reson. Med. 1998 40(2): 311-326.
  4. Atalar E, Kraitchman DL, Carkhuff B, Lesho J, Ocali O, Solaiyappan M, Guttman MA, Charles HK: Catheter-tracking FOV MR Fluoroscopy, Magn. Reson. Med. 1998 40(6):865-872.
  5. Kraitchman DL, Hillenbrand HB, Oznur I, Lima JAC, McVeigh ER, Zerhouni EA, Bluemke DA: Noninvasive assessment of myocardial stunning from short-term coronary occlusion using tagged MRI, J Cardiovasc Magn Reson, 2000 2(2): 113-126.
  6. Kraitchman DL, Bluemke DA, Chin BB, Heldman AW, Heldman AW: A minimally invasive method for creating coronary stenosis in a swine model for noninvasive MR and SPECT imaging, Investigative Radiology 2000 35(7):445-451.
  7. Constantinides CD, Kraitchman D, Brien KO, Boada FE, Gillen J, Bottomley PA: Noninvasive quantification of total sodium concentration in acute reperfused myocardial infarction using 23Na MRI, Magn Reson Med 2001 46:1144-1151.
  8. Kraitchman DL, Chin BB, Heldman AW, Bluemke DA: MRI detection of perfusion defects due to coronary artery stenosis with MS-325, J Magn Reson Imaging, 2002 15:149-158.
  9. Chin BB, Esposito G, Kraitchman DL: Simultaneous assessment of myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine 99mTc-sestamibi SPECT in canine stunning and subendocardial infarction.  Correlation with MRI myocardial tagging and postmortem pathology, J Nucl Med, 2002 43(4):540-550.
  10. Gerber BL, Bluemke DA, Chin BB, Heldman AW, Boston RC, Lima JAC, Kraitchman DL: Single vessel coronary artery stenosis: myocardial perfusion imaging using Gadomer-17 first-pass MRI in a swine model of comparison with Gadolinium-DTPA. Radiology, 2002 225(1):104-121.
  11. Kraitchman DL, Sampath S, Castillo E, Derbyshire JA, Boston RC, Bluemke DA, Gerber BL, Prince JL, Osman NF: Quantitative ischemia detection during cardiac magnetic resonance stress testing using FastHARP. Circulation, 2003 107(15): 2025-2030.
  12. Kraitchman DL, Heldman AW, Atalar E, Amado LC, Martin BJ, Pittenger M, Hare JM, Bulte JWM: In-vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction, Circulation, 2003 107(18): 2290-2293.
  13. Karmarkar P, Kraitchman DL, Izbudak I, Hofmann LV, Amado LC, Fritzges D, Young RG, Pittenger MF, Bulte JWM, Atalar E: MR trackable intramyocardial injection catheter, Magn Reson Med, 2004 51:1163–1172.
  14. Rosen BD, Gerber BL, Edvardsen T, Castillo E, Amado L, Nasir K, Kraitchman DL, Osman NF, Bluemke DA, Lima JAC: Late systolic onset of regional left ventricular relaxation demonstrated in three dimensional space by MRI tissue tagging. American Journal of Physiology, 2004 287(4):H1740-1746.
  15. Bulte JWM, Kraitchman DL, Mackay AM, Pittenger MF: Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides. Blood, 2004 104(10):9410-9412.
  16. Bulte JWM, Kraitchman DL: Monitoring cell therapy using iron oxide MR contrast agents. Current Pharmaceutical Biotechnology, 2004 5(6):567-584.
  17. Amado LC, Gerber BL, Gupta SN, Rettmann DW, Szarf G, Schock R, Nasir K, Kraitchman DL*, Lima JAC*: Accurate and objective infarct sizing by contrast enhanced MRI in a canine myocardial infarction model. Journal of American College of Cardiology, 2004 14(12):2383-2389.
  18. Foo TKF, Ho VB, Saranathan M, Cheng L, Sakuma H, Kraitchman DL, Wu KC, Bluemke DA: High resolution 3D breath-held MR coronary artery imaging: Feasibility of integration with myocardial perfusion and viability studies. Radiology, 2005 235(3):1025-1030.
  19. Foo TK, Wolff SD, Gupta SN, Kraitchman DL: Enhanced viability imaging: Improved contrast in myocardial delayed enhancement using dual inversion time subtraction. Magn Reson Med, 2005 53(6):1484-1489.
  20. Bulte JW, Kostura L, Mackay A, Karmarkar PV, Izbudak I, Atalar E, Fritzges D, Rodriguez ER, Young RG, Marcelino M,  Pittenger MF, Kraitchman DL: Feridex-labeled mesenchymal stem cells cellular differentiation and MR assessment in a canine myocardial infarction model.  Acad Radiol, 2005 12(1): S2-6.
  21. Azevedo CF, Amado LC, Kraitchman DL, Gerber BL, Edvardsen T, Osman NF, Rochitte CE, Wu KC, Lima JA: The effect of intra-aortic balloon counterpulsation on left ventricular functional recovery early after acute myocardial infarction: a randomized experimental magnetic resonance imaging study. Eur Heart J, 2005 26:1235-1241.
  22. Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, Segars WP, Chen H,  et. al.: Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction, Circulation,2005 112: 1454-1464.
  23. Rickers, C, Kraitchman D, Fischer G, Kramer HH, Wilke N, Jerosch-Herold M: Cardiovascular interventional MR imaging: a new road for therapy and repair in the heart. Magn Reson Imaging Clin N Am, 2005. 13(3): p. 465-79.
  24. Matsuhashi T, Kraitchman DL, Hofmann LV: Therapeutic Angiogenesis. Endovascular Today, July 2005: 17-30.
  25. Faranesh, AZ, Kraitchman DL, McVeigh ER: Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent. Magn Reson Med, 2006. 55(5): p. 1114-23.
  26. Pan L, Stuber M, Kraitchman DL, Fritzges DL, Gilson WD, Osman N: Real-time imaging of regional myocardial function using fast-SENC. Magn Reson Med, 2006 Feb;55(2):386-395.
  27. Kraitchman DL, M. Stuber, W.D. Gilson, L.V. Hofmann, and JWM Bulte, Novel magnetic resonance contract mechanism for combined tracking of the delivery of mesenchymal stem cells and interventional devices. Contrast Media & Molecular Imaging, 2006 2(1): p.76-77.
  28. Kramer CM, Neubauer S, Kraitchman D, Higgins CB, Fogel MA, Friedrich MG, and Manning WJ: Meeting highlights of the 9th annual scientific sessions of the society for cardiovascular magnetic resonance: Miami, Florida, January 20-22,2006. J Am Coll Cardiol, 2006 48(1): p. 187-92.
  29. Barnett B, Kraitchman DL, Lauzon C, Magee CA, Walczak P, Gilson WD, Arepally A, Bulte JWM: Radiopaque alginate microcapsules for X-ray visualization and immunoprotection of cellular therapeutics. Molecular Pharmaceutics, 2006 3: 531-538.
  30. Barnett B, Arepally A, Karmarkar P, Qian D, Gilson WD, Walczak P, Howland V, Lawler L, Lauzon C, Stuber M, Kraitchman DL, Bulte JWM: Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nature Medicine, 2007 13(8):986-991.
  31. Gilson WD, Kraitchman DL: Cardiac magnetic resonance imaging in small rodents using clinical 1.5T and 3.0 T scanners. Methods, 2007 43: 35-45.
  32. Stuber M, Gilson WD, Schar M, Kedziorek DA, Hofmann LV, Shah S, Vonken E, Bulte JWM, Kraitchman DL: Positive contrast visualization of iron oxide-labeled stem cells using Inversion Recovery with ON-resonant water suppression (IRON), 2007 58:1072–1077.
  33. Korosoglou G, Gilson WD, Schar M, Ustun A, Hofmann LV, Kraitchman DL, Stuber M: T2-prepared 3T magnetic resonance angiography compared with time-of-flight MRA in a rabbit model of hindlimb ischemia. Radiology, 2007 245(3): 762-769.
  34. Kraitchman DL, Gilson WD, Lorenz CL: Stem cell therapy: MRI guidance and monitoring. J Magn Reson Imaging, 2008 28(2): 299-310.
  35. Kraitchman DL and Bulte JWM: Imaging stem cells with MRI. Basic Res Cardiol, 2008 103: 105-113.
  36. Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schar M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M: Positive contrast MR-lymphography using inversion recovery with ON-resonant water Suppression (IRON). Magn Reson Med, 2008 27(5):1175-1180.
  37. Gerber BL, Raman SV, Nayak K, Epstein FH, Ferreira P, Axel L, Kraitchman DL: Cardiac First-pass Perfusion Imaging - History, Theory, and Current State of the Art. J Cardiovasc Magn Reson, 2008 10(1):18.
  38. Korosoglou G, Weiss RG, Kedziorek DA, Walczek P, Gilson WD , Schar M, Sosnovik D, Kraitchman DL, Boston RC,  Bulte JW, Weissleder R, Stuber M: Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. J Am Coll Cardiol, 2008 Aug 5;52(6):483-91.
  39. Korosoglou G, Shah S, Vonken EJ, Gilson WD , Schar M, Tang L, Kraitchman DL, Boston RC,  Sosnovik D, Weiss RG, Weissleder R, Stuber M: Off-resonance angiography: A new method to depict vessels - phantom and rabbit studies. Radiology, 2008 doi:2491071706.
  40. Gyöngysi, M, Blanco J, Marian T, Trón L, Petneházy Ö, Petrasi Z, Hemetsberger R, Rodriguez J, Font G, Pvao IJ, Kertész I, Balkay L, Pavo N, Posa A, Emri M, Galuska L, Kraitchman DL, Wojta J, Huber K, Glogar D: Serial non-invasive in vivo positron emission yomographic (PET) tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression. Circ Cardiovasc Imaging, 2008 doi:10.1161.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Contact Information:

Phone: 410.955.4892
FAX: 410.614.1977
email: dara@mri.jhu.edu

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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