The Medical Imaging Lab was established in 1991 in the Department
of Biomedical Engineering with funding from a Whitaker
Foundation Development Award. The faculty and students associated with
the lab are interested in the development of new imaging techniques and
advanced applications of existing techniques to solve problems in medicine
and biology. A training program in medical imaging has been established
in the department for both undergraduate and graduate students. To find
out more about this go to the Biomedical Imaging
Selected Research Topics
Imaging the heart and cardiovascular system with magnetic resonance presents
many challenges. Issues such as bio-compatibility, magnetic resonance physics,
patient monitoring, image analysis, computer visualization, and clinical
stress testing must be tackled simultaneously by a diverse research team.
For example, magnetic resonance-compatible pacemakers have been designed
and built; real-time quantitative magnetic resonance stress testing and
fluoroscopy is being performed; and the effect of conduction abnormalities
and pacing in the failing heart is being examined in patients.
Cengizhan Ozturk, MD, PhD
BME: Real-Time Cardiac Function Analysis and Tissue Tracking
Ergin Atalar, PhD, EE: Image Analysis, MRI catheter
coils, MR compatible devices
David Bluemke, MD, PhD: Cardiovascular MRI,
MRI Stress Testing
Paul Bottomley, PhD, Physics: Myocardial
Metabolism, MRI coils
Mike Guttman MS, Biomed Eng: Image Analysis,
John Forder,PhD Biochemistry: Myocardial Metabolism,
Elias Zerhouni, MD MRI Stress Testing,
David Kass, MD: Cardiovascular Mechanics, Pacing in Heart Failure
Ronald Berger, MD, PhD EE: Electrophysiology, RF ablation therapy,
MR catheter coils
Henry Halperin, MD, MS, Physics, MR compatible devices
Joao Lima, MD: Echocardiography, MRI Stress Testing
Hugh Calkins, MD: Electrophysiology, Atrial Fibrilation, RF ablation,
MR catheter coils
James Weiss, MD: Myocardial Wall Motion with MRI tagging in Ischemia
Robert Weiss, MD: Myocardial Metabolism
Gary Gerstenblith, MD: Myocardial Metabolism
Bradley Bolster BS, MSE EE: Vascular Compliance,
MRI catheter coils
Chris Constantinides MS, BME: MR Evaluation
of Myocardial Metabolism
Cecilia Curry BS :
Chris Moore BS, Aerospace Eng, MD/PhD, BME:
Wall Motion During Ischemia
PhD, BME: Myocardial Strain, Myocardial Fiber Angle Measurements
Scott Reeder BSc, Engineering
Physics; MSE, BME: Ultra-Fast Magnetic Resonance Cardiac Imaging
Tessa Sundaram BS BME, CS:
of Global Heart Properties Using Magnetic Resonance Imaging
Brad Wyman BS, EE; MS EE:
For a complete bibliography press here. Some
hypertext and PDF papers of recent projects are given below.
S.R. Reeder, "Assessment of Myocardial
Viability with MRI"
High Resolution Intravascular MRI
and MRS using a Catheter Receiver Coil. E. Atalar, P.A. Bottomley,
O. Ocali, L.C. Correia, M.D. Kelemen, J.A.C. Lima and E.A. Zerhouni. (Accepted
for publication in Magnetic Resonance in Medicine)
MRI of Myocardial Function: Motion
(Magn. Reson. Imag. 14(2):137-150 (1996)).
Pencil Excitation with Interleaved
Fourier Velocity Encoding: NMR Measurement of Aortic Distensibility
Christopher J. Hardy, *Bradley D. Bolster, Jr., *Elliot R. McVeigh,
Icko E. T. Iben, *Elias A. Zerhouni:
(in press, Magn. Reson. Med.)
Cardiac Tagging with Breath-hold
E.R. McVeigh and E. Atalar,
(Magn. Reson. Med. 28:318-327 (1992)).
Visualization and Analysis of Functional
Cardiac MRI Data
E.R. McVeigh, M.A. Guttman et. al.,
(SPIE Proceedings Vol. 2168 (1994), ISBN 0-8194-1463-8)
Minimization of Dead Periods in
MRI Pulse Sequences for Imaging Oblique Planes. E. Atalar and E.R.
McVeigh (originally published in Magn. Reson. Med. Vol 32, No 6, pp. 773-777,
Optimization of Tag Thickness for Measuring
Position with Magnetic Resonance Imaging. E. Atalar and E.R. McVeigh
(originally published in IEEE
Trans. on Medical Imaging Vol 13, No 1, pp. 152-160, March 1994.)
Displacement Field Fitting
forCalculating 3D Myocardial Deformations from Tagged MR Images
W.G. O'Dell, C.C. Moore, W. Hunter, E.A. Zerhouni,
(Radiology, 195:829-835 (1995))
Multi-shot EPI for Improvement
of Myocardial Tag Contrast: Comparison with Segmented SPGR.
Chao Tang, Elliot R. McVeigh, Elias A. Zerhouni.
(Magn. Reson. Med. 33(3):443-447 (1995))
for Rapid Noninvasive Cardiac Assessment
M. Solaiyappan, T. Poston, P.A. Heng, E.R. McVeigh, M.A. Guttman, E.A.
(in press, IEEE, Computer)
and Visualization of Cardiac Function from MR Images
M. A. Guttman, E.A. Zerhouni and E. R. McVeigh:
(IEEE, Computer Graphics and Applications)
Ultra-High Resolution Imaging of
Esophagel Wall using a Quadrature Detector Placed within Gut Ergin
Atalar, Elias A. Zerhouni, and Pankaj Jay Pasricha. ISMRM Fourth Scientific
Meeting, NY, NY, 1996.
A Flexible Catheter Coil
for Imaging and Spectroscopy of Atherosclerotic Plaques. Ergin Atalar,
Paul A. Bottomley, and Elias A. Zerhouni, SMR/ESMRBM Joint Meeting, Nice,
A Phased Array Coil for
In-Vivo Microscopic MR Imaging of Breast Lesions. Ergin Atalar and
Elias A. Zerhouni, SMR/ESMRBM Joint Meeting, Nice, France, 1995.
Temporal Evolution of Three
Dimensional Deformation in the Ischemic Human Left Ventricle: Assessment
by MR Tagging. Carlos H. Lugo-Olivieri, M.D., et. al.
resolution of 3D cardiac tagging reconstruction: Impulse response analysis
for displacement field-fitting. Society of Magnetic Resonance, Book
of Abstracts, Vol 3., 1417, (1995) W.G. ODell, C.C. Moore, E.A. Zerhouni,
Additional Information of Interest.
This mpeg movie shows the combination of a reconstructed LV with the
original imaging data, visualized on the SGI Reality Engine. This shows
how precise mechanical information can be displayed in the original context
of the imaging data. The tags and color are displayed on the calculated
epicardial surface. The color represents radial thickening ( [low] yellow
--> [high] red ).
Homepage provides a manual and tutorial for running the tag strain
analysis application, TEA, which uses the displacement field-fitting approach
to calculate 3D deformations from parallel-tagged MR images. (maintained
by Walter O'Dell at UCSD)
||A graph for making a T1/T2 phantom, showing how much CuSO4 and agar
to mix to get the T1 and T2 you want.
Imaging Lab Meeting Schedule
Medical Imaging Laboratory
Departments of Biomedical Engineering and Radiology
425 Traylor Bldg., 720 Rutland Ave.
Johns Hopkins University School of Medicine
Baltimore, MD 21205
For directions to the Traylor Building look at the Medical School campus
firstname.lastname@example.org, December 1995.
Last updated 10/1/97